【Aim】 Tuta absoluta is a type of worldwide invasive pest that causes destructive damage to tomatoes. To provide a theoretical basis for the scientific control of T. absoluta production, we determined the toxicity and control effect of various pesticides against T. absoluta larvae. 【Method】 The toxicity regression equation of each pesticide on different instar larvae was calculated using toxicity measurements. The efficacy of each pesticide on larvae was determined from 1 to 21 days after treatment via field efficacy evaluation. The control effects of various types of pesticides on tomato leaf miner were comprehensively analyzed. Further the control effects of various insecticides on T. absoluta were compared and analyzed using indoor toxicity tests and field trials. 【Result】 The results of indoor toxicity tests showed that the sensitivities of azadirachtin and emamectin benzoate were the strongest toward T. absoluta. Azadirachtin exhibited the strongest toxicity against the 1st instar larvae, with an LC₅₀ value of 3.22 mg·L^-1. The toxicity of emamectin benzoate was strongest against the 2nd-4th instar larvae, with LC₅₀ values of 7.1046, 7.5663, and 4.375 mg·L^-1, respectively. This was followed by chlorphenamide and ethyl polybactericide. Beta-cypermethrin and methoxyfenozide also exhibited high toxicity against T. absoluta. The sensitivities of imidacloprid, thiamethoxam, and nitenpyram against T. absoluta were relatively weak. The results of the field control showed that emamectin benzoate had the best control effect and persistence, with control effects of 74.11%, 71.42%, and 60.03% on the 7th, 14th, and 21st days after treatment, respectively, followed by chloramphenicol, ethyl polybactericide, and beta-cypermethrin. Azadirachtin exhibited good persistence, and the control effect of azadirachtin was greater than 50%, 7-21 days after treatment. Methoxyfenozide, imidacloprid, thiamethoxam, and nitenpyram exerted relatively weak effects on T. absoluta. 【Conclusion】 Emamectin benzoate, chloramphenicol benzamide, and ethyl polybactericide, which have good application prospects, could be used as the first choice of pesticides to control T. absoluta in production. Azadirachtin and beta cyhalothrin could be used alternatively.