【Aim】 Cyclachaena xanthiifolia (Nuttall) Fresenius is an invasive weed species. The aim of predicting its potential habitat and conducting a risk assessment in Xinjiang is to provide a scientific reference for effective prevention and control in our region.【Method】 The MaxEnt model and ArcGIS 10.4 software were utilized to analyze and predict the potential distribution area of C. xanthiifolia in Xinjiang. Additionally, the classification of risk levels was performed. Furthermore, the multi-index comprehensive evaluation method was employed to comprehensively analyze and assess the hazard risk of C. xanthiifolia. 【Result】 The suitable area for C. xanthiifolia in Xinjiang is predominantly situated in the northern region, covering a wide expanse. Highly adaptable areas include Karamay City, the northern part of Changji Hui Autonomous Prefecture, and the central part of Tacheng District. Key environmental factors influencing the distribution of C. xanthiifolia encompass the annual average temperature (bio1), the average temperature in the driest season (bio9), the average temperature in the coldest season (bio11), and the average temperature in the hottest season (bio10). The comprehensive risk assessment value of C. xanthiifolia is 2.238, indicating its classification as a highly dangerous pest. 【Conclusion】 Though C. xanthiifolia is confined to Tacheng, Xinjiang, prediction results suggest a potential expansion of its coverage in northern Xinjiang. Therefore, proactive management and control measures should be devised accordingly.