The invasive weed, Tithonia diversifolia A. Gray poses a considerable threat to biodiversity and ecosystem function in the tropical and subtropical regions of China, due to its rapid expansion. To improve awareness of the impact caused by T. diversifolia, it is imperative to enhance monitoring, early warning, and control measures. This study is a thorough review of a range of literature. We present a comprehensive analysis of the impacts of T. diversifolia invasion and expansion across various countries and regions. The historical background and distribution and its impact on genetic, species, and ecosystem diversity are described. Combined with scientific research and application practices of the ecological invasion prevention and control technology of T. diversifolia, the main problems and challenges of the ecological invasion prevention and control technology of T. diversifolia are presented. To effectively monitor and prevent the ecological invasion of T. diversifolia, a multi-level risk assessment should be conducted. Diversified scientific research should be conducted on the expansion of the invasion. Early monitoring, prevention, and warning mechanisms should be established; and a comprehensive technical system for prevention and control should be constructed.