【Aim】 This study aimed to explore the relationship between Mikania micrantha invasion, terrain factors, and human disturbance to quantify the influence of different disturbance factors on the occurrence of M. micrantha. This was done to further reveal the pattern of occurrence of M. micrantha and to provide technical support for the systematic prevention and control of M. micrantha. 【Method】 Using high-resolution aerial photos obtained by using a UAV remote sensing system as the data source, the occurrence area of M. micrantha was determined by visual interpretation. The relationship between the occurrence of M. micrantha in the 210000 m² study area of the Dapeng Peninsula in Shenzhen and topographic factors as well as human disturbance was systematically analyzed by combining 3S technology. 【Result】 The results showed that 86.80% of the M. micrantha invasions in the study area occurred in areas with low-to-moderate human disturbance. M. micrantha is mainly distributed in low-altitude areas and sunny slopes, and 20°-40° is the incline with the highest occurrence of M. micrantha. The occurrence area of M. micrantha in the grid unit of the study area was negatively correlated with the slope and altitude (P<0.01) but was not significantly related to the aspect. 【Conclusion】 Under natural conditions with low human disturbance, the main factor limiting the spread of M. micrantha is the community structure of the invasion site, whereas, in areas with more severe human disturbance, the occurrence of M. micrantha invasion is closely related to the empty ecological niche created after the disappearance of human activities.