Abstract:【Aim】 To further effectively control the harm caused by the Pomacea canaliculata and provide the basis for the resource utilization of Chinese herbal medicine. 【Method】 Using licorice and tangerine peel as plant molluscicidal agents, the molluscicidal activity of licorice and tangerine peel soaked in extracts with different concentration gradients (0, 0.5, 1.5, 3.0, 4.5, and 6.0 g·L-1) was studied. 【Result】 With the change of time, the mortality of P. canaliculata in licorice group and orange peel group was significantly poisoned at different concentrations. The mortality data of P. canaliculatas at 48 hours were analyzed by probability unit regression method. It was found that the licorice group (LC 25, LC 50, LC 75) was less than the tangerine peel group (LC 25, LC50, LC 75), indicating that P. canaliculatas were more sensitive to licorice. In order to further explore the causes of death of P. canaliculatas, the effects of licorice and tangerine peel extracts on the liver of P. canaliculatas were deeply discussed on the basis of previous studies. The sublethal concentrations of licorice 0.511 g·L-1 (LC25), 0.940 g·L-1 (LC50), 1.727 g·L-1 (LC75) and tangerine peel 3.892 g·L-1 (LC25), 4.863 g·L-1 (LC50) and 6.076 g·L-1 (LC75) were determined. The results showed that compared with the control group, the liver tissue surface of the treatment group was dry and lost water. When the damage was serious, the texture was loose and the surface tissue fell off. 【Conclusion】 The two plant extracts can kill P. canaliculata well and seriously damage the liver of the core tissue of P. canaliculata. Licorice and tangerine peel can be used as plant molluscicides for further research, development and utilization.