[Aim] Scatopse sp. is one of the dangerous pests hampering the production of edible fungi. In this study, the toxicity of insecticides and the inhibition of mycelial growth of Pleurotus ostreatus were tested to identify ideal insecticides for controlling Scatopse sp.[Method] The virulence of five insecticides to Scatopse sp. larvae was tested using baits, and the inhibition of P. ostreatus mycelial growth by the insecticides was studied.[Result] The adjusted mortality rates of fenpropathrin 20% emulsifiable concentrates, ivermectin chlorfenacaronitrile 14% suspending concentrates, and emavil and pyriproxyfen 20% suspending concentrates were more than 80%. They have good toxic effects on Scatopse sp. larvae. However, the efficacy of Bacillus thuringiensis suspension against Scatopse sp. larvae was not satisfactory. The five insecticides inhibited the mycelial growth of P. ostreatus, and significant differences among the varieties were found. The inhibition rate of 20% cypermethrin emulsifiable concentrates was the highest (16.85%) at a concentration of 480 mg·L^-1, whereas that of 14% ivermectin chlorfenacaronitrile suspending concentrates was the lowest (5.83%) at 140 mg·L^-1.[Conclusion] In conclusion, 14% ivermectin chlorfenacaronitrile suspending concentrates has the best effect for controlling Scatopse sp in P. ostreatus among the tested. The results of this study provide important theoretical guidance for controlling Scatopse sp.