The European grapevine moth Lobesia botrana is an important economic pest on grapes. It is a polyphagous and multivoltine species with strong adaption to environmental stresses. This pest originated in Europe and has successfully colonized many countries around the world. Larvae of the moth mainly feed on grape inflorescences, green fruits and mature fruits, causing great losses in grape production. The pest can cause damage that can increase fungal infection, leading to gray mold and powdery mildew. Due to the extremely high risk of L. botrana invasion, it has been listed as an important entry quarantine pest in China. Chemical control is the major approach of controlling European grapevine moth in different countries. With the long-term and unreasonable use of chemical pesticides, this pest has developed resistance to different types of pesticides. In this paper, we summarize the insecticide resistance measurement methods, as well as the resistance status and mechanisms of the pest to different insecticides. We propose some potential management strategies to reduce resistance development.