Species invasion has threatened many countries around the world, seriously affecting agricultural, forestry, husbandry and fishery production, threatening ecosystem stability, and is one of the major reasons for global biodiversity loss. The prevention and control of invasive alien species has become a research hotspot of current biodiversity conservation and sustainable agricultural development. China has become one of the countries with the most serious threats from and losses of biological invasions in the world, with nearly 800 species invading by the end of 2018, and 638 species of invasive agroforest ecosystems identified. All 31 provinces (autonomous regions and municipalities) have invasive species involving almost all the type of ecosystems and thus causing damage. To promote the prevention and control of invasive alien species national legislations are now mainstream. China government has initially established a working mechanism for the prevention and control of invasive alien species, successfully issued a list of 52 key invasive alien species, organized for species survey every year, setup a national wide network for monitoring of key species, and carried out control measures in some key areas. Based on the experience of foreign countries controlling invasive alien species and the author's many years of work experience, this paper puts forward some suggestions on the prevention and control measures of invasive species, including strengthening the legal system construction, including the Law of Biosecurity, conducting background general investigations, strengthening long-term monitoring and forecasting, starting major invasion prevention and control projects. It would provide reference for the prevention and control of invasive alien species in China.