Northeast-Eastern Inner Mongolian (NEIM) area includes Liaoning, Jilin, Heilongjiang and east areas of Inner Mongolia. The NEIM area is an important window for the exchanges of foreign economies, trades, technologies and cultures. The NEIM is one of the most centralized important regions of grain production in China. However, in the NEIM, the management level of agricultural production and the capacity to respond to agricultural disaster problems are lagging behind. Invasion of many important harmful organisms and migratory pests occur in these provinces and neighboring countries. They not only cause losses of agricultural output and quality, but also seriously impair international trade of our national agricultural products. With the implementation of the national grand strategy of "the Belt and Road" (B&R) initiative, the unwanted invasion of dangerous pests may also inadvertently increase and become a prominent cause further problems in agricultural production. The questions are therefore how to; secure the safety of agricultural production in the NEIM area, reduce the risk of the possible invasion of harmful and dangerous pests, protect the national ecological environment, and promote international trade of our agricultural products. In this article, we discuss the strategies of implementation of the B&R strategy as an opportunity to establish a whole chain of green plant protection techniques, containing the early warning, intelligent monitoring and integrated pest prevention and control systems, that are cover edrelevant for the whole NEIM; the integration of the advantage of comprehensive strength of crop integrated pest management (IPM) in the NEIM region, with mainly in association with the plant-protection related organizations, educational institutions, personnel of science and technology popularization or and extension services in Russia, South Korea and other neighboring countries to build the an international union system of plant protection in Northeast China.