Mikania micrantha is a major alien invasive species in the Lang Cangjiang-Mekong River subregion. The cross-border invasion and expansion of M. micrantha have attracted great attention of governments and society in the region. Since 2011, with the technical support of relevant agricultural scientific research institutions, teams and experts from Yunnan, China, and five surrounding countries have rapidly established the "Greater Mekong Subregion Plant Protection Working Group". This paper briefly introduces the achievements of the working group on the early warning and monitoring of population expansion and impacts of M. micrantha in various environmental conditions, the development of quarantine and control zones, and the synergistic application of alternative controls and selective herbicides. This work is consistent with the implementation of the national "the Belt and Road Initiative", and plays a constructive role in supporting economic, and ecological development in Yunnan, China.