With the current trend in global economic integration, the harm of alien invasive species is increasingly becoming a serious issue. Aiming at the threat of major invasive species, China has carried out a series of research projects on three aspects:common key technologies, major product development, and typical application demonstration. These projects resulted in understanding the invasion characteristics and mechanisms of invasive species, and the interaction mechanisms of invasive plants in fragile ecosystems. Risk assessment and control technologies for major new invasive agricultural species have been developed. Biological threat databases, a visual intelligent decision support platform for emergencies, and major management strategies and technology systems for invasive plants and animals have been established. A major invasive biological specimen repository has also been developed. In the future, cross-border animals and plants should be the main targets to carry out research on invasion and dispersion patterns, early warning, rapid detection and monitoring, identification and tracking, point interception and eradication, and regional disaster prevention and mitigation.