【Background】Mikania micrantha is the invasive plant and Cerataphis lataniae is the important pest in coconut palm, the research on control of C. lataniae was seldom carried, so the research on the biological activity of M. micrantha secondary compounds on Cerataphis lataniaemay provide reference for the use of M. micrantha and control of C. lataniae. 【Method】The stomach and contact toxicities of M. micrantha extracts from 4 solvents (cyclohexane, n-butanol, acetone, petroleum ether) were studied. 【Result】N-butanol and acetone extracts showed higher activities than cyclohexane or petroleum ether extracts in contact toxicity, and the LC50 values were 12.96 mg·mL-1 and 12.48 mg·mL-1, respectively. No significant differences were found among the contact toxicities of 4 M. micrantha extracts to C. lataniae， and the LC50 of cyclohexane extract, n-butanol extract, acetone extract and petroleum ether extract of M. micrantha were 15.28 mg·mL-1, 12.28 mg·mL-1, 11.40 mg·mL-1 and 16.62 mg·mL-1, respectively. 【Conclusion and significance】M. micrantha extracts have potential to control C. lataniae.