【Background】Lambda-cyhalothrin and thiamethoxam are common agricultural insecticides. 【Method】Virulence of 0.25 g·L-1 lambda-cyhalothrin aqueous capsule suspension and 0.01% thiamethoxam gel bait against Solenopsis invicta were tested in laboratory. 【Result】The lambda-cyhalothrin microcapsule suspension showed active contact toxicities on S.invicta with a short exposure time, high mortality rate, and effective transduction rate. Thiamethoxam gel bait was successfully transferred between workers and larval ants by feeding worker ants. Under these conditions, up to 93.5% of the colony could be killed in laboratory conditions. 【Conclusion and significance】The results indicated that both insecticides could be used as effective agent for fire ant control.