【Background】Mikania micrantha H.B.K.is one of the most dangerous weeds worldwide, and has invaded Taiwan, Hongkong, as well as Guangdong, Hainan, and Yunnan Provinces of China where it causes serious damages. Sulfometuron methyl is an efficient herbicide against M.micrantha control, and we sought methods to enhance its effect by mixing the herbicide with different surfactants. 【Method】By the methods of field spraying and laboratory bioassay, we tested the control effects of sulfometuron methyl mixed with detergent or diesel on root, steam and leaf tissues of M.micrantha. We also studied the effect on germination rate of residual stems and seeds. 【Result】Twentyeight days after treatment by sulfometuron methyl alone, the mortality of leaf, steam and root were 86%, 92% and 84% respectively. The same mortality values were 98.33%, 97.67% and 89.67% after mixed with detergent and 92.33%, 95.33% and 98.33% when mixed with diesel oil, respectively. The re-sprouting rate of residual stems treated by sulfometuron methyl alone was 9.67%, and this was reduced to 6% and 5.33% after mixing with detergent and diesel oil, respectively. Seed germination rate was 44.67% when treated with sulfometuron methyl alone, and it was decreased to 28.67% and 25.33% after mixed with detergent and diesel, respectively. 【Conclusion and significance】Sulfometuron methyl had bigger effect when mixed with detergent or diesel on plant tissues, germination rate of residual steam and seeds than when used alone. The results will provide reference for M.micrantha control.