【Background】Mikania micrantha, an invasive exotic weed, caused serious economic losses to the local agriculture and forestry. It is therefore important to select herbicides that will effectively control the growth of M.micrantha. 【Method】Nine herbicides species, glyphosate, picloram, sulfometuron, thifensulfuron, tribenuronmethyl, paraquat, penoxsuam, monosulfuron and monosulfuron ester were tested for the effectiveness to control M.micrantha. After spraying the herbicides on M.micrantha, the inhibition rate in terms of fresh weight, leaf coverage, and the suppression rate on the flowering were measured. 【Result】Picloram 25~100 g ai·hm-2, glyphosate 1538~2306 g ai·hm-2, sulfometuron methyl 100~400 g ai·hm-2, paraquat 750, 1125 g ai·hm-2, penoxsuam 125 g ai·hm-2, thifensulfuron 11.25~33.75 g ai·hm-2 and monosulfuron ester 15~60 g ai·hm-2 were highly effective in controlling the weed M.micrantha and had little effect on the rubber trees in our experimental fields. Paraquat was the most effective in short time. Glyphosate, penoxsuam, monosulfuron ester, monosulfuron, picloram, and sulfometuron had strong inhibitive effect on flowering of M.micrantha, but tribenuronmethyl and monosulfuron were ineffective. 【Conclusion and significance】Reducing reasonably the concentration of picloram, mexolamine, glyphosate, penoxsuam, thifensulfuronmethyl and monosulfuron ester can maintain vegetative growth but inhibit flowering, thus seed dispersal. This is the first experiment showing that penoxsuam, thifensulfuronmethyl and monosulfuron ester can effectively control M.micrantha.