【Background】Alternanthera philoxeroides is an invasive plant which originated from South America and is currently spreading in China. Nimbya alternantherae isolate SF193 is a phytopathogenic fungus which could cause foliar and stem necrosis of A.philoxeroides and inhibit the growth of the weed in the field. 【Method】Agricultural byproducts, such as bran, rice, powder of corn cob, cornmeal, rice stover, cotton seed hull, rice husk, and soybean powder were selected as basic or auxiliary material to develop a solidstate medium for growing the pathogen isolate SF193. Further, the effect of water and metal ion content in the solidstate medium on the growth of the fungus was investigated. 【Result】The area of colony was the largest when the isolate SF193 was cultured on media composed of rice and soybean powder with ratios of 3∶[KG-*2]1 and 5∶[KG-*2]1, respectively, follwed by the mix of rice and cotton seed hull with ratio 5∶[KG-*2]1. The colony areas of the isolate SF193 cultured in the media containing 20% and 30% water were significant larger than those of media with different water content. Compared with control, the area of colony measured on the media with Mg2+ and Mn2+ had no significantly difference. Colony growth was inhibited on media containing Zn2+, while no colony was observed on media containing Cu2+ and Fe3+. Under field conditions, disease severity causd by the fungal powder was significantly higher than that obtained by liquid fermentation and reached 86.[KG-*8]1 at dosage of 50 g·m-2. 【Conclusion and significance】The efficiency [JP2]controlling of A.philoxeroides by using the fungal powder fermented was remarkably higher than that of the fungus fermented[JP] with liquid media. These results suggested that isolate SF193 powder fermented by solidstate fermentation could potentially play a role in biocontrol of A.philoxeroides.